Police are at the scene of a serious crash that has closed the Omarama-Otematata Road (State Highway 83) at the intersection of Prohibition Road.

Emergency services were called at 12.35pm, after two vehicles, one towing a caravan, collided.

Initial indications suggest two people are in a moderate condition and two people are in a serious condition.

The Serious Crash Unit has been advised.

Traffic management is being arranged. However, motorists should expect delays and postpone travel if possible.