Central Otago police have made another dent in the region's drug trade after an operation last week.

Alexandra Police Sergeant Adam Elder said on Friday Police executed a search warrant at a Roxburgh house where five indoor tents housing 12 mature cannabis plants were located.

"Alongside the plants, a quantity of already dried-out cannabis was located packaged, which Police will allege was ready for distribution.

''Three high-powered air rifles were also located at the address and have since been seized, as he was not permitted to be in possession of them,'' he said.

A 55-year-old man is due to reappear in the Alexandra District Court on Thursday on charges of possession of cannabis for supply, cultivating cannabis, and possessing equipment to cultivate cannabis.

In another raid the same day at a different Roxburgh property, Police located a large amount of drug paraphernalia, including utensils believed to be used for smoking methamphetamine, in a house bus. 

Inquiries are ongoing.

Sgt Elder said police would continue to crack down on the illegal supply of drugs, and were working with the community to address the underlying drivers of demand.

''If you have any information that may assist Police in identifying those involved in the illegal supply of drugs please contact Police,'' he said.